Protein Therapeutics

Vibha Jawa, Leslie P. Cousens, Michel Awwad, Eric Wakshull, Harald Kropshofer, Anne S. De Groot, T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation, Clinical Immunology, Volume 149, Issue 3, Part B, December 2013, Pages 534-555, ISSN 1521-6616, http://dx.doi.org/10.1016/j.clim.2013.09.006.
(http://www.sciencedirect.com/science/article/pii/S152166161300243X)

Moise L, Song C, Martin WD, Tassone R, De Groot AS, Scott DW. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo. Clin Immunol. 2012 Mar;142(3):320-31. http://bit.ly/epiFVIII

Jawa, V., Cousens, L., & De Groot, A. S. (2013). Immunogenicity of Therapeutic Fusion proteins: Contributory Factors and Clinical Experience. Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges, 75-90. http://bit.ly/epiFcFuse

Scott DW, De Groot AS. Can we prevent immunogenicity of human protein drugs? Ann Rheum Dis. 2010 Jan;69 Suppl 1:i72-76. doi: 10.1136/ard.2009.  http://bit.ly/epiImmPr

Weber CA, Mehta PJ, Ardito M, Moise L, Martin B, De Groot AS. T cell epitope: friend or foe? Immunogenicity of biologics in context.Adv Drug Deliv Rev. 2009 Sep 30;61(11):965-76.  http://bit.ly/epiFrnFoe

De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol. 2009 May;131(2):189-201. http://bit.ly/epiClinIm

De Groot AS, McMurry J, Moise L. Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates. Curr Opin Pharmacol. 2008 Oct;8(5):620-6. http://bit.ly/epiPredIm

De Groot AS, Moise L. Prediction of immunogenicity for therapeutic proteins: state of the art. Curr Opin Drug Discov Devel. 2007 May;10(3):332-40 http://bit.ly/epiStoArt

De Groot AS, Scott DW. Immunogenicity of protein therapeutics. Trends Immunol. 2007 Nov;28(11):482-90. Epub 2007 Oct 25 http://bit.ly/epiImTrend

Koren E, De Groot AS, Jawa V, Beck KD, Boone T, Rivera D, Li L, Mytych D, Koscec M, Weeraratne D, Swanson S, Martin W. Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein. Clin Immunol. 2007 Jul. http://bit.ly/epiClinVal