Tregitope Publications

Tregitope Publications with Links to Full PDF’s


    • Anne S De Groot, “Do Tregitopes have the potential to impact the current treatment landscape of autoimmune diseases?” Expert Review of Clinical Immunology 2013 9:12, 1155-1157.  Full PDF.


    • Anne S. De Groot, Leslie Cousens, Federico Mingozzi, and William Martin, “Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?,” Clinical and Developmental Immunology, vol. 2013, Article ID 493138, 6 pages, 2013. doi:10.1155/2013/493138, LINKED HEREPDF HERE


    • De Groot AS, Terry F, Cousens L. and Martin W.  Beyond humanization and de-immunization: toleration as a method for reducing the immunogenicity of biologics. Expert Rev Clin Pharmacol.  Nov 2013


    • Daniel J. Hui, et al. Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes. Molecular Therapy. July 2013.


    • Leslie P. Cousens, Anne S. De Groot,  David W. Scott, et al. Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se. J. Leukocyte Biology. May 2013


    • Leslie P. Cousens, Yan Sb, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott Anne S. De Groot Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes. April 2013


    • Cousens, Mingozzi, van der Marel, Su, Garman, Ferreira, Martin, Scott, and De Groot. Teaching tolerance: New approaches to enzyme replacement therapy for Pompe disease. Hum Vacc & Immunother. Oct 2012


    • Cousens, Najafian, Mingozzi, Elyaman, Mazer, Moise, Messitt, Su, Sayegh, Khoury, Scott, De Groot. In vitro and in vivo studies of IgG-Derived Treg epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity. J Clin Immunol. Epub Sep 2012


    • Cousens, Tassone, Mazer, Ramachandiran, Scott, De Groot. Tregitope update: Mechanism of action parallels IVIG. Autoimmun Rev. 2012 Aug 28. [Epub ahead of print]. PMID: 22944299.


    • van der Marel S, Majowicz A, Kwikkers K, van Logtenstein R, te Velde AA, De Groot AS, Meijer SL, van Deventer SJ, Petry H, Hommes DW, Ferreira V.  Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis. World J Gastroenterol. Aug 2012.


    • Elyaman W, Khoury SJ, Scott DW, De Groot AS. Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis. Neurol Res Int. Apr 2011.


  • De Groot AS, Moise L, McMurry JA, Wambre E, Van Overvelt L, Moingeon P, Scott DW, Martin W. Activation of Natural Regulatory T cells by IgG Fc-derived Peptide “Tregitopes”. Blood. Oct 2008.