by Annie De Groot | Oct 26, 2017 | EpiVax Immunoncology, Thinking Out Loud -Blog
Yes, wonder drugs though they are, checkpoint inhibitors (a.k.a CPI) drive anti-drug antibodies (ADA) too. We’ve been concerned for a while that “releasing the brakes” will drive T cell response to CPI, and have been watching to see what happens....
by Annie De Groot | Nov 26, 2013 | News
Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics Expert Rev. Clin. Pharmacol. 6(6), 651–662 (2013) Abstract Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their...
by Annie De Groot | Oct 4, 2012 | Thinking Out Loud -Blog
Another drug gets into trouble. What’s the worry? Well, ask yourself. Do you want a drug that causes immune responses to your own endogenous proteins? We thought not. Read on: “Novo Nordisk scuttles late-stage hemophilia drug over patient risk”...